Adjusted multivariate logistic regression models were built to assess associations between Lp(a)-related biomarkers and stroke subtype.<h4>Results</h4>In participants with acute ischemic stroke, high Lp(a) concentrations, percentage of APOB in Lp(a), and OxPL-APO(a) concentrations were significantly associated with the presence of atherosclerotic stroke compared to those with non-atherosclerotic strokes [OR = 1.30 (<i>p</i> = 5.7e - 3), 1.29 (<i>p</i> = 6.9e - 3), 1.27 (<i>p</i> = 1.7e - 2), respectively]. This evidence concerns the gene AOPEP and stroke disorder.