<h4>Background</h4>Primary hemostasis is impaired in cirrhosis, characterized by thrombocytopenia, platelet dysfunction, elevated von Willebrand Factor (VWF) levels, and reduced a disintegrin-like metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) activity. This evidence concerns the gene ADAMTS13 and Thrombocytopenia.