This study aimed to develop and validate a preoperative prognostic model combining tumor burden score (TBS), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9), termed the TCCA model, to predict outcomes in patients with ICC undergoing hepatectomy.<h4>Methods</h4>Patients who underwent curative resection for ICC between 2014 and 2020 were retrospectively identified from a multi-institutional database. The gene discussed is CEACAM5; the disease is intrahepatic cholangiocarcinoma.