Two murine renal fibrosis models were established to validate the expression of hub genes and to assess their associations with immune-cell infiltration.<h4>Results</h4>We identified five hub LRGs-<i>IKZF1, PDLIM1, S100A11, STAT4</i> and <i>SLC2A3</i>-that were strongly associated with renal allograft fibrosis. This evidence concerns the gene S100A11 and renal fibrosis.