Small B-cell lymphoma highly suspicious for splenic marginal zone lymphoma with &lt;i&gt;MYD88&lt;/i&gt; L265P mutation and &lt;i&gt;MYC&lt;/i&gt; copy-number gain presenting as severe autoimmune hemolytic anemia: a case report with literature review. The gene discussed is MYD88; the disease is autoimmune hemolytic anemia.