LYVE1 and asthma: This study aimed to investigate the association between soluble LYVE-1 (sLYVE-1) levels and asthma severity, airway inflammation, and remodeling, and to elucidate its regulatory role in airway smooth muscle cell (ASMC) activation via the PI3K/Akt signaling pathway.<h4>Methods</h4>A total of 238 participants were enrolled, including 80 healthy controls, 72 patients with asthma who were in remission, and 86 patients with acute asthma.