<i>In vitro</i>, LYVE-1 silencing markedly attenuated PDGF-BB-induced PI3K/Akt phosphorylation, ASMC proliferation and migration, extracellular matrix-related gene expression, and pro-inflammatory cytokine secretion while reducing oxidative stress and enhancing antioxidant activity.<h4>Conclusion</h4>Elevated circulating sLYVE-1 levels are closely associated with asthma severity, airway inflammation, and airway remodeling. Here, LYVE1 is linked to asthma.