Among A allele carriers, OB-related indicators (BMI, RMR, WHR) were independently associated with age, sex, RMR, SBP, ALT, leptin, and dietary intakes of Vit A and sugars.<h4>Conclusions</h4>These findings support the relevance of <i>BDNF</i> rs6265 in obesity phenotypes among Korean adults and provide Korean-specific evidence for genotype-based nutrition strategies. This evidence concerns the gene BDNF and obesity due to melanocortin 4 receptor deficiency.