Infection/sepsis was more frequently the cause of death within five years after HTX among patients with a pre-transplant CRP ≥ 20 mg/L (28.4% vs. 15.8%, <i>p</i> = 0.005), particularly pulmonary infections (19.6% vs. 9.5%, <i>p</i> = 0.006). Here, CRP is linked to infection.