This study investigated whether three well-established osteoporosis-related polymorphisms-<i>SOST</i> rs1513670, <i>LRP5</i> rs3736228, and <i>ESR1</i> rs6929137-derived from a commercial genetic testing panel (HelloGeneTM) were primarily associated with osteoporosis prevalence and/or incidence and secondarily with bone-related biochemical markers in a Korean population. This evidence concerns the gene ESR1 and osteoporosis.