qPCR analysis showed lower <i>HIF-1α</i>, <i>BNIP3L</i>, and <i>HMGB1</i> expression in ATD-treated groups, which is consistent with attenuation of hypoxia-related, mitochondrial stress-associated, and damage-associated molecular pattern-associated signaling after injury. This evidence concerns the gene HMGB1 and Jeune syndrome.