In this study, we evaluated two PPARδ agonists, KD3010 and T3D-959, in two established ALS/FTD mouse models: an AAV-mediated C9orf72 G4C2-repeat expansion model (C9-149R) and the TDP-43<sup>Q331K</sup> transgenic model. Here, C9orf72 is linked to amyotrophic lateral sclerosis.