CASP8 and autoimmune lymphoproliferative syndrome: CASP3 mRNA was also increased in both patient groups versus controls (ALPS: <i>p</i> = 0.0045; ITP: <i>p</i> < 0.0001), with no significant difference between ALPS and ITP (<i>p</i> = 0.1692).<h4>Conclusions</h4>ALPS and chronic ITP show distinct CASP8 transcriptional patterns and a shared upregulation of CASP3 at the whole-blood mRNA level.