Subsequently, we assessed the expression levels of Angelman syndrome-related neighboring and target genes at the transcript and, where applicable, protein levels.<h4>Results</h4>Following treatment with si<i>Snord115</i> or LV-sh<i>Snord115</i>, we observed a reduction in <i>Ube3a-ATS</i> and a corresponding activation of paternal <i>Ube3a</i> RNA and protein expression in both <i>Ube3a</i><sup>P-YFP/m+</sup> and <i>Ube3a</i><sup>p+/m-</sup> mouse primary neurons. Here, SNORD115 is linked to Angelman syndrome.