Regulatory networks involving microRNAs (miRNAs) and transcription factors (TFs) were also examined.<h4>Results</h4>Shared hub genes were identified across COVID-19 and cancer datasets, including <i>IGF1</i>, <i>MMP9</i>, and <i>NOTCH1</i> in TNBC; <i>TOP2A</i>, <i>PXN</i>, and <i>CCNB1</i> in breast cancer; and <i>ASPM</i> and <i>TTK</i> in ccRCC. This evidence concerns the gene TOP2A and cancer.