However, whether GMK can ameliorate global cerebral ischemia-reperfusion injury (GCIRI) and its associated cognitive deficit remains to be elucidated.<h4>Methods</h4>GCIRI was induced in male Sprague-Dawley rats by bilateral common carotid artery occlusion with hypovolemia (BCCAO/H). This evidence concerns the gene GUK1 and Cerebral ischemia.