PIK3CA and non-small cell lung carcinoma: <b>Background/Objectives</b>: Alterations of the phosphatidylinositol 3-kinase catalytic subunit alpha gene (<i>PIK3CA</i>) are identified in approximately 2-4% of non-small cell lung cancer (NSCLC) cases; however, their biological and clinical relevance in NSCLC remains incompletely understood.