LDLR and atherosclerosis: <b>Conclusions</b>: Our results indicate that HFD-treated LDLR-KO mice develop atherosclerosis with functional contractile and structural alterations modulated by CB<sub>1</sub>Rs: absence of CB<sub>1</sub>Rs elicited higher contraction properties with some modification in vascular remodeling indicating contribution of the CB<sub>1</sub>R to cellular signalization controlling wall thickness and elasticity in pathological conditions.