MLH1 and neoplasm: Mechanistically, we detail how Western-style diets drive a specific "epigenetic double-hit": promoting global DNA hypomethylation (destabilizing LINE-1) while paradoxically inducing promoter hypermethylation of critical tumour suppressors (<i>MLH1</i>, <i>APC</i>, <i>MGMT</i>) and silencing tumour-suppressive microRNAs (miR-34b/c, miR-137) via methylation of their encoding genes.