IL6 and osteosarcoma: We show the antitumor properties of a <i>Griffonia</i> seed extract, obtained by maceration in a hydroalcoholic mixture (ethanol/water, 70/30, <i>v</i>/<i>v</i>, Gri70), on osteosarcoma cell lines, evaluating cytotoxicity, interaction with a pro-inflammatory signal (interleukin-1β), epigenetic activity of this signal on interleukin-6 gene expression, and interactions with an elective chemotherapeutic agent, doxorubicin.