CD8A and psychiatric disorder: Single-cell SMR indicated that increased <i>ENDOG</i> expression was associated with higher SCZ risk in astrocytes, CD4<sup>+</sup> naïve T cells, CD8<sup>+</sup> effector T cells, and natural killer cells, suggesting a potential immune-brain interaction.<h4>Conclusions</h4>This study provides multi-level genetic evidence supportive of a potential causal role for specific OSGs in major psychiatric disorders.