HAGH and posterior cortical atrophy: Here, after confirming our previous findings, we demonstrate-using Glo2 silencing, ectopic expression, pharmacological inhibitors, and exogenous D-lactate supplementation-that Glo2-dependent D-lactate accumulation promotes EMT-like plasticity, migration, and invasion in PTEN-deficient PCa cells via a functional link with FAK/Src signaling.