Overall, these findings indicate that the dinner GI influences fasting glucose levels in adults with obesity; the <i>FAAH</i> variant predicted lower insulin and HOMA-IR levels, supporting a plausible chrono-nutrigenetic interaction between carbohydrate quality, mealtime intake, and <i>FAAH</i> variation in metabolic regulation, which must be further studied. The gene discussed is INS; the disease is Obesity.