This review synthesises biological insights provided by advanced MRI in preoperative IDHwt GBM.<h4>Methods</h4>We conducted a scoping review following the PRISMA-ScR framework, querying five databases (PubMed, Scopus, Cochrane, EBSCO, and Embase) to identify literature using advanced MRI to investigate biological correlates in IDHwt GBM.<h4>Results</h4>MRS ratios were associated with tumour presence and Ki-67 expression. This evidence concerns the gene MKI67 and glioblastoma.