<b>Methods:</b> Using a The Cancer Genome Atlas (TCGA) glioblastoma, IDH-wildtype discovery cohort, we identified gene-level DNA methylation and expression patterns associated with clinical outcomes, including epigenetically regulated genes such as <i>TUBB2A</i> and <i>TM4SF1</i>. The gene discussed is IDH1; the disease is glioblastoma.