<b>Methods:</b> Using a The Cancer Genome Atlas (TCGA) glioblastoma, IDH-wildtype discovery cohort, we identified gene-level DNA methylation and expression patterns associated with clinical outcomes, including epigenetically regulated genes such as <i>TUBB2A</i> and <i>TM4SF1</i>. This evidence concerns the gene TM4SF1 and glioblastoma.