Investigation of primary breast cancer cultures derived from pre-neoadjuvant biopsies also revealed that HER2-enriched primary breast cancer cells displayed heightened chemosensitisation to doxorubicin (Adriamycin), which was not recapitulated in TNBC cultures.<h4>Conclusions</h4>Our data highlight the presence of contextual parameters which govern the degree of EMT regulation by eribulin. This evidence concerns the gene ERBB2 and breast carcinoma.