While some studies suggest protective effects, others raise concerns about potential oncogenic associations.<h4>Objective</h4>To investigate the risk of common cancers with GLP-1RA initiation.<h4>Design</h4>Retrospective cohort study.<h4>Participants and main measures</h4>Patients diagnosed with type 2 diabetes between 2013-2021 were identified using IBM-MarketScan database and were categorized into exposure (i.e., GLP-1RA) and comparison (i.e., insulin) groups. This evidence concerns the gene INS and type 2 diabetes mellitus.