However, its biological and clinical significance in clear cell renal cell carcinoma (ccRCC) remains poorly understood.<h4>Methods</h4>We conducted a comprehensive analysis using several public datasets (TCGA KIRC, JAVELIN101, IMmotion151, and others) and a Hiroshima ccRCC cohort (n = 110) to evaluate the expression of KIFC1, clinicopathological associations, the prognosis, and treatment response. This evidence concerns the gene KIFC1 and nonpapillary renal cell carcinoma.