After controlling for relevant confounding variables, including obesity, women experiencing occupational stress showed a 15% higher probability of elevated leptin levels compared with those without occupational stress (prevalence ratio [PR] = 1.15; 95% CI: 1.02-1.30; <i>p</i> = 0.022).<h4>Conclusions</h4>Occupational stress was independently linked to increased serum leptin concentrations among female workers, suggesting that psychosocial stressors in the workplace may play a role in the disruption of leptin regulation in this population. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.