Here we investigated whether PDLIM2, a known regulator of both epithelial and immune cell fate, contributes to colitis progression.<h4>Methods</h4>PDLIM2 knockout mice (-/-) and wildtype littermates (+/+) were assessed for responses to dextran sodium sulphate (DSS)-induced colitis, and to aoxymethane +DSS. Here, PDLIM2 is linked to colitis.