Mechanistic studies were carried out in Caco-2 cell cultures, and in silico analysis was carried out on single cell RNA sequencing data from patients with Ulcerative colitis or Crohn's disease.<h4>Results and discussion</h4>Compared to PDLIM2 +/+ mice, PDLIM2 -/- mice exhibited exacerbated and unresolved epithelial damage and inflammation accompanied by immune cell infiltration, which was precluded sufficient time to observe tunour development. The gene discussed is PDLIM2; the disease is ulcerative colitis.