IGHE and infection: Mechanistically, pharmacologic and expression-based perturbations suggested that mTORC2-Akt signaling can cooperate with the Notch pathway to fine-tune IgG1 versus IgE isotype selection.<h4>Conclusion</h4>Together, these findings define a PTEN-mTORC2-Akt signaling module within the PI3K network that shapes antibody isotype selection and antiviral humoral immunity, highlighting a potential target for precision modulation of antibody responses in infection, vaccination, and inflammatory diseases.