While T cell-mediated immunity in tuberculosis is well characterized, alterations in circulating B-cell subsets during chronic MDR-TB are less well defined.<h4>Methods</h4>Peripheral blood mononuclear cells (PBMCs) from healthy controls [interferon gamma release assay negative (IGRA<sup>-</sup>)], individuals with latent tuberculosis infection (LTBI; IGRA<sup>+</sup>), and patients with active tuberculosis (ATB) were analyzed using multiparameter flow cytometry panels. Here, IFNG is linked to tuberculosis.