Moreover, the combination of plasma APOL1 and lymphocyte count (LYM) demonstrated high diagnostic efficacy for NEC, with an AUC value of 0.96 (sensitivity 93.3% and specificity 93.3%).<h4>Conclusions</h4>Our findings reveal a marked upregulation of APOL1 in preterm infants with NEC. The gene discussed is APOL1; the disease is necrotizing enterocolitis.