Serum levels of osteocalcin (OC), parathyroid hormone (PTH), sclerostin (SOST), fibroblast growth factor 23 (FGF23), Dickkopf-1 (DKK1), osteoprotegerin (OPG), and osteopontin (OPN) were assessed.<h4>Results</h4>The IBD group demonstrated a statistically significant higher OPN value (<i>p</i> < 0.001) compared to the control group. This evidence concerns the gene SPP1 and inflammatory bowel disease.