The anti-gingivitis and anti-periodontitis effects of DKB140 were demonstrated in RAW 264.7 macrophages and human gingival fibroblasts (hGF-1) using enzyme-linked immunosorbent assay (ELISA), reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and western blot analysis by investigating the NLRP3 signaling pathway and its inhibitory effects on matrix metalloproteinase (MMP) expression and osteoclast differentiation. Here, NLRP3 is linked to periodontitis.