B cell receptor (BCR) signalling was studied through downstream phosphorylation in vitro.<h4>Results</h4>Patients with active SLE showed increased frequencies of CD72-negative B cells in switched memory (SWM), activated naïve (aNAV), DN2 and plasmablast (PB) subsets compared with healthy controls (HCs). The gene discussed is CD72; the disease is systemic lupus erythematosus.