G6PD and malaria: Combined approaches enhanced effectiveness in high-resistance or high-burden settings, while complex strategies, such as tafenoquine with G6PD screening, showed higher ICERs due to additional costs and operational challenges.<h4>Conclusion</h4>Most malaria interventions in Sub-Saharan Africa were highly cost-effective, including LLINs (with PBO nets), IRS (Actellic/3GIRS), combined LLIN + IRS, SMC/PDMC, IPTp, and ACT + RDT.