However, DCs remain insufficiently characterized in MDD.<h4>Methods</h4>We performed an exploratory study using flow cytometry-based immunophenotyping to assess circulating DC subsets, including CD1c<sup>+</sup> and CD141<sup>+</sup> conventional DCs (cDCs), plasmacytoid DCs (pDCs), and their cytokine profiles in individuals with MDD (<i>n</i> = 55) and healthy controls (HC, <i>n</i> = 32). Here, CD1C is linked to major depressive disorder.