Regarding cytokine-producing DCs, sex-stratified analyses showed that frequencies of IL-23<sup>+</sup> cDCs were elevated and symptom-associated only in females with MDD compared to sex-matched controls, whereas frequencies of TNF<sup>+</sup>, IL-1β<sup>+</sup>, and IL-6<sup>+</sup> cDCs were selectively increased in depressed males. The gene discussed is IL6; the disease is major depressive disorder.