Finally, NF-κB inhibitors directly suppressed Trm cell activation and inflammation of Trm cells <i>in vitro</i>.<h4>Conclusion</h4>Together, these findings suggest that canonical and non-canonical NF-κB signaling directly activates Trm cell differentiation, inhibits cellular cuproptosis, and promotes recurrent psoriasis. The gene discussed is NFKB1; the disease is psoriasis.