Key proteins such as adhE, NDK, treA, and ackA were markedly elevated, while galE and Ter family proteins were uniquely present in CRKP-OMVs, indicating potential roles in resistance and pathogenicity.<h4>Conclusions</h4>CRKP-derived OMVs from sepsis patients exhibit distinct protein enrichment patterns associated with membrane functions, metabolic remodeling, and antibiotic resistance. Here, TREH is linked to Sepsis.