While CLK1 has been implicated in Alzheimer's disease, pancreatic cancer proliferation, and chemotherapy resistance in lymphoma, its role in NSCLC, particularly in the context of tumor immune infiltration, remains unexplored.<h4>Methods</h4>CLK1 expression and prognostic significance were analyzed across cancers and in LUAD using bioinformatics platforms (GEPIA, UALCAN). Here, CLK1 is linked to cancer.