Our purpose was to assess whether STING activation stimulates the repolarization of TANs toward the N1 subtype and to investigate the potential participation of TANs in metastasis and macrophage polarization processes.<h4>Methods</h4>This research was carried out on murine B16-F10 melanoma and 4T1 breast carcinomas. The gene discussed is STING1; the disease is melanoma.