Histological staining (H&E and Masson), immunohistochemistry, and Western blotting were used for tissue-level validation, while cellular experiments were performed in keloid fibroblasts with autophagy modulation.<h4>Results</h4>ADRB2 and PLK2 were consistently identified as key autophagy-related candidate genes. The gene discussed is ADRB2; the disease is keloid.