ESR1 and breast cancer: In contrast, HER-2 IHC score showed no significant correlation with lymph node status or clinical stage (<i>P</i>>0.05).<h4>Conclusions</h4>BC patients exhibit characteristic alterations in Ki67, ER, and PR immunohistochemical expression, and the degree of Ki67 increase together with ER and PR decrease is closely associated with lymph node metastasis and clinical disease stage.