The study was conducted with the objectives to compare the relative expression of MEG3 lnc-RNA in patients of Type-II DM, with and without DKD, and to determine the correlation of this expression with blood and urine biomarkers.<h4>Methodology</h4>A cross-sectional study was conducted at the University of Health Sciences, Lahore, after ethical approval from December 2022 till October 2023. This evidence concerns the gene MEG3 and diabetic kidney disease.