There was a significant positive correlation between MEG3 expression and fasting insulin in the DKD group, a significant negative correlation with fasting insulin in the DM group, a significant negative correlation with serum very low-density lipoproteins in the healthy group, and a significant negative correlation between MEG3 lnc-RNA expression and urinary creatinine in the DKD group.<h4>Conclusions</h4>MEG3 lnc-RNA has a higher relative expression in the patients suffering from DKD in the local diabetic population. The gene discussed is INS; the disease is diabetic kidney disease.