When stratified into survival and non-survival groups, the non-survivors exhibited significantly higher levels of TNF-α, IL-10, HBP and APACHE-II scores(<i>P</i>< 0.005, respectively).<h4>Conclusion</h4>Serum levels of TNF-α, IL-10 and HBP are positively correlated with sepsis severity. The gene discussed is TNF; the disease is Sepsis.