The patients in the APO group were further divided into two subgroups, those who were evaluated within 3 days of onset and those who were evaluated after 3 days of onset, and the former subgroup was found to have lower serum PRL and sodium level as well as higher body temperature. Hyperthermia, hyponatremia, and hypoprolactinemia indicate the possibility of pituitary apoplexy.Trial number: E-2020-2022, June 1, 2022, retrospectively registered. This evidence concerns the gene PRL and pituitary apoplexy.