Several genes linked to regenerative processes (e.g., MEGF10, SOX4) were differentially expressed, but canonical myogenic and catabolic regulators remained unchanged, indicating that CKD muscle exists in a transcriptionally blunted state rather than one of overt inflammation or proteolysis.<h4>Conclusions</h4>CKD skeletal muscle is characterised by suppression of immune and ECM regulatory programmes, with limited evidence for activation of classical inflammatory or degradative pathways. This evidence concerns the gene MEGF10 and chronic kidney disease.