Importantly, intratracheal transfer of <i>IL-10<sup>+/+</sup></i> CD11b<sup>+</sup>Ly6G<sup>+</sup>Ly6C<sup>+</sup> cells 1 day before infection to <i>Thbs1<sup>-/-</sup></i> mice restored their ability to produce IL-10 in the lungs, improved host defense, and reduced lung inflammation and permeability upon infection. This evidence concerns the gene ITGAM and infection.