This study aimed to investigate UBE2D1 expression in HNSCC, evaluate its prognostic significance while acknowledging disease heterogeneity, including HPV and TP53 status, and explore its potential association with response to anti-PD-1 immunotherapy.<h4>Methods</h4>UBE2D1 mRNA and protein expression were analyzed using the Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma (TCGA-HNSCC) dataset via the UALCAN platform. This evidence concerns the gene UBE2D1 and head and neck squamous cell carcinoma.