<h4>Objectives</h4>To investigate the effects of swimming on bone loss and the OPG/RANKL/RANK pathway in ovariectomized (OVX) osteoporotic rats.<h4>Methods</h4>Twenty female SD rats were randomly divided into a sham-operated group, a ovariectomized osteoporosis group, a short-duration exercise group, and a long-duration exercise group. This evidence concerns the gene TNFRSF11A and osteoporosis.