The mRNA and protein expression of OPG, RANKL, and RANK in bone tissue were detected by qRT-PCR and Western bolt, respectively.<h4>Results</h4>After swimming treatment, compared with the ovariectomized osteoporosis group, BV/TV, BMD, Tb.Th, and Tb.N increased, while Tb.Sp decreased; CTX-I, TRAP-5b, BGP, and BALP levels decreased. The gene discussed is TNFRSF11A; the disease is osteoporosis.